DOI: 10.69601/meandrosmdj.1927246 ISSN: 2149-9063

Assessment of NLRP3, Caspase-1, and IL-18 Levels in Pediatric Sepsis

Sadullah Toprak, Murat Arı, Hatice Feray Arı, İsmail Koyuncu
Show PDF Cite
Backround: Pediatric sepsis remains a leading cause of critical illness and mortality among children admitted to pediatric intensive care units (PICU). Early and accurate diagnosis is essential for timely intervention and improved clinical outcomes. Recent evidence suggests that inflammasome-related biomarkers, including NOD-like receptor family pyrin domain-containing 3 (NLRP3), caspase-1, and interleukin-18 (IL-18), may play important roles in the pathophysiology of sepsis. This study aimed to evaluate the diagnostic utility of NLRP3, caspase-1, and IL-18 levels in pediatric sepsis.Methods: This prospective case–control study included 60 pediatric patients admitted to the PICU between November 2022 and January 2023, including 30 with sepsis and 30 non-septic controls. Serum NLRP3, caspase-1, and IL-18 levels were measured by ELISA within 48 hours of diagnosis. Demographic, clinical, laboratory, and PRISM III data were collected and compared between groups.Results: NLRP3, caspase-1, and IL-18 levels were significantly higher in the sepsis group compared to controls (p 

More from our Archive