Assessing and Comparing Potential Allergenicity of Two Partially Hydrolyzed Whey‐Based Formulas for Infants: A Population‐Based Study in China
Lijuan Sun, Shiwen Han, Sufang Duan, Like Mao, Fang Li, Zhenhua Tu, Huilian Che- Food Science
- Biotechnology
Scope
In cases where breast milk is unavailable or inadequate, hydrolyzed infant formula is recommended as the primary alternative. The aim of this study is to assess and compare the allergenicity of two partially hydrolyzed whey‐based formulas (PHF‐Ws) using serum samples from patients with cow's milk allergy (CMA).
Methods and results
LC‐MS/MS technology is used to investigate the peptide distribution in both samples. The immunoreactivity of two PHF‐Ws in 27 serum samples from 50 Chinese infants (02 years) with CMA is analyzed. The results demonstrate that even with a similar a degree of hydrolysis (DH), primary protein sources, peptides with molecular weights <5 kDa, and differences in the number of residual allergenic epitopes in the hydrolyzed peptide segments can lead to varying immune responses.
Conclusion
The two PHF‐Ws have notably high intolerance rates, exceeding 10% among infants with CMA. Therefore, suggesting that PHF‐Ws may not be suitable for infants and children with CMA in China.