DOI: 10.1039/d4cc04594g ISSN: 1359-7345
ARCaDia: single-round screening of a DNA-type targeted covalent binder possessing a latent warhead
Masumi Taki, Masayasu Kuwahara, Chaohui Li, Naoko Tomoda, Naoyuki Miyashita, Tetsuo Kan, Jay YangA covalent binder was identified using a single-round screening from a latent-warhead-modified DNA library, coupled with top k-mer analysis to pinpoint the optimal warhead position on the aptamer.