Dhiraj Kumar, R. K.Mishra

ANTIMICROBIAL SUSCEPTIBILITY PATTERN OF PSEUDOMONAS AERUGINOSA ISOLATES FROM VARIOUS CLINICAL SAMPLES AT A TERTIARY CARE HOSPITAL, JAIPUR RAJASTHAN.

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Background: Pseudomonas aeruginosa is one of the most common pathogens isolated from a variety of clinical samples. Furthermore, Pseudomonas aeruginosa is also one of the common pathogens responsible for generalized sepsis and subsequent mortality. Thus, it becomes critical to keep track of the prevailing drug sensitivity pattern of Pseudomonas species. This study aims to determine the antibiotic Objective: susceptibility pattern of Pseudomonas aeruginosa isolates in patients admitted to different clinical wards. This was a Material and Methods: single centre, laboratory-based, cross-sectional study conducted over a period of 14 months (May 2021 to June 2022) at the Department of Microbiology, SMS Medical College, Jaipur. The isolates were identied by standard protocols using biochemical tests. A total of 132 clinical samples in which the causative organism was Pseudomonas aeruginosa was tested for drug sensitivity and resistance pattern using as per Clinical and Laboratory Standards Institute (CLSI) guidelines using Kirby-Bauer's disc diffusion method. The mean and median age of the Results participants was 31.8 years and 28 years, respectively, ranging from a minimum of 8 days to a maximum of 80 years. All the 132 (100.0%) isolates were sensitive to Colistin, followed by Piperacillin & Tazobactam (87.8%), Aztreonam (75%), Amikacin (75%), and Imipenem (74.2%). The isolates of Pseudomonas aeruginosa were least sensitive antibiotics to cefoperazone + sulbactam (65.2%), ciprooxacin (65.9%), and tobramycin (67.4%). Pseudomonas aeruginosa is one of the commonly isolated opportunistic pathogen and it Conclusion: is becoming more resistant to commonly used antibiotics. Carbapenems and aminoglycosides were the two classes of drugs that showed highest activity against Pseudomonas aeruginosa.

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