Antimicrobial and Anti-arthritic Studies of Metal (II) Complexes of Schiff Base Derived from 2 – Hydroxy - 1- Naphthaldehyde

Copper(II), zinc(II), and cobalt(II) complexes of Schiff base derivatives of 2-hydroxy-1-naphthaldehyde with 4-bromo aniline were prepared for the current study. These complexes were then characterized using several spectrum analyses, including UV-Vis spectra, FTIR spectra, 1HNMR, 13CNMR and XRD. The disc diffusion method was used to assess the bacterial activity. The complexes showed more antibacterial activity than the ligand. Many useful anti-cancer metal-based drugs have been introduced. However, less attention has been paid to the improvement of anti-arthritic drugs based on metal complexes. So, anti-arthritic properties were computed. The synthesized compounds were evaluated for their anti-arthritic by using egg albumin denaturation method. It was found that copper complex had the lowest IC50 value (6.53 μg/ml) and hence was the most active one. These findings support the use of schiff base complex in the management of long-term inflammatory conditions and suggest that it may be a candidate for the discovery of novel anti-arthritic chemicals.