DOI: 10.59313/jsr-a.1816079 ISSN: 2687-6167

Antimicrobial activity studies of salt and metal complexes of 2-aminobenzothiazole derivatives and 2,6-pyridinedicarboxylic acid

Halil İlkimen, Cengiz Yenikaya, Aysel Gülbandılar
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In this study, the salts {(Habt)(Hdpc) (3), (Habt)(Hdpc)2 (6), (HMeabt)(Hdpc).H2O (12), (HMeOabt)(Hdpc) (18)} obtained from 2,6-pyridinedicarboxylic acid (H2dpc) and 2-aminobenzothiazole (abt), 2-amino-6-chlorobenzothiazole (Clabt), 2-amino-6-methylbenzothiazole (Meabt), and 2-amino-6-methoxybenzothiazole (MeOabt), and metal complexes of 1 {Fe(III) (Habt)[Fe(dpc)].4H2O (2), Co(II) (Habt)2[Co(dpc)].3H2O (3), Ni(II) (Habt)2[Ni(dpc)].4H2O (4), Cu(II) [Cu(dpc)(abt)(H2O)] (5)}, of 6 {Fe(III) (HClabt)[Fe(dpc)].5H2O (7), Co(II) (HClabt)2[Co(dpc)].H2O (8), Ni(II) (HClabt)2[Ni(dpc)].H2O (9), Cu(II) [Cu(dpc)(Clabt)(H2O)]2 (10), Cu(II) (HClabt)2[Cu(dpc)].H2O (11)}, of 12 {Fe(II) (HMeabt)2[Fe(dpc)].H2O (13), Fe(III) (HMeabt)[Fe(dpc)].5H2O (14), Co(II) (HMeabt)2[Co(dpc)].H2O (15), Ni(II) (HMeabt)2[Ni(dpc)].H2O (16), Cu(II) (HMeabt)2[Cu(dpc)].H2O (17)}, of 18 {Fe(III) (HMeOabt)[Fe(dpc)].2H2O (19), Co(II) (HMeOabt)2[Co(dpc)].4H2O (20), Ni(II) (HMeOabt)2[Ni(dpc)].H2O (21), Cu(II) (HMeOabt)2[Cu(dpc)].H2O (22)} were synthesized by the methods found in the literature. The metal percentages in the structures of the synthesized compounds (2-5, 7-11, 14-17, and 19-22) were compared with those in the literature using Atomic Absorption Spectroscopy (AAS). Furthermore, the antimicrobial properties of all compounds have also been tested against C. albicans (antifungal activity) and E. Coli, P. aeruginosa, B. subtilis, S. aureus, L. monocytogenes, and E. faecalis (antibacterial activity). The results were compared with those obtained using the control compounds Fluconazole and Ketoconazole (antifungal activity) and Vancomycin, Levofloxacin, Cefepime, and Chloramphenicol (antibacterial activity). As a result of activity studies, newly synthesized compounds show activity against bacteria and yeasts. Specifically, compound 9 demonstrated superior activity against all bacteria and yeasts. Compounds Clabt and 18 showed good activity against C. albicans compared to control compounds. In conclusion, it is suggested that all compounds have potential applications in inhibiting bacterial and yeast growth. Consequently, all compounds are proposed to have potential applications in inhibiting bacterial and yeast growth.

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