Antihypertensive Effects of Quercetin-Rich Marchin-13 in a Dexamethasone-Induced Rat Model

The study aimed to evaluate the antihypertensive effect of Marchin-13 traditional prescription (M13T) in the dexamethasone-induced model of hypertension. Quercetin, a biologically active substance contained in M13T, was identified by HPLC analysis. Forty rats were randomly assigned to five different groups. The experimental groups induced hypertension models by dexamethasone (20 mcg/kg/day). Blood pressure was assessed in the tail with a Neurobotic Systole 1.2 instrument on days 5, 8, 13, and 15. The serum levels of renin, ANGII, aldosterone, and AT1R were measured in all groups by ELISA. Our research determined that the quercetin content in M13T is 0.255 mg/g. In the dexamethasone-induced hypertension model, M13T significantly reduced SBP, DBP, and MAP on days 8, 13, and 15 (p < 0.01). Moreover, the renin, ANGII, AT1R, and aldosterone levels were significantly reduced in the captopril and M13T groups compared to the DEX group (p < 0.01). As a result of our study, M13T has an antihypertensive effect by reducing serum renin, angiotensin II, AT1R, and aldosterone levels in hypertensive rats induced by dexamethasone.