Antidiabetic and Antidyslipidemic Effects of Artemisia mesatlantica, an Endemic Plant from Morocco
Adil Qabouche, Ayoub Amssayef, Ismail Bouadid, Nadia Lahrach, Ahmed EL-Haidani, Mohamed Eddouks- Cardiology and Cardiovascular Medicine
- Pharmacology
- Hematology
- Molecular Medicine
- General Medicine
Aims:
The study aimed to assess the antihyperglycemic and antidyslipidemic activities of Artemisia mesatlantica.
Background:
Artemisia mesatlantica is an endemic plant of Morocco used in traditional medicine as an alternative treatment for diabetes.
Objective:
The study was designed to examine the antihyperglycemic and antidyslipidemicability of aqueous extract of Artemisia mesatlantica (AMAE) in experimental animal models.
Methods:
The effect of the single and repeated oral administration (7 days of treatment) of AMAE (60 mg/kg) on blood glucose and lipid profile were assessed in normal and streptozotocin-induced diabetic rats. Furthermore, to confirm the antidyslipidemic effect of Artemisia mesatlantica, a model of hyperlipidemia induced by tyloxapol (Triton WR-1339) in rats was used.
Results:
The AMAE (60 mg/kg) was able to significantly reduce glycaemia, improve lipid profile and increase hepatic glycogen content in STZ-induced diabetic rats. In addition, pretreatment of rats for 7 consecutive days with an aqueous extract of Artemisia mesatlantica (600 mg/kg) prior to tyloxapol injection prevented increases in plasma levels of total cholesterol, triglycerides and LDL-c.
Conclusion:
From these observed results, it can be deduced that Artemisia mesatlantica possesses remarkable antidiabetic and antihyperlipidemic properties.