DOI: 10.1039/d5cs00617a ISSN: 0306-0012
Antibacterial drug discovery: challenges and preclinical promises from synthetic small molecules
Guilherme F. S. Fernandes, Seong-Heun Kim, Jean L. Dos Santos, Yuhang Wang, Christelle Soudy, Joanna Redmond, Daniele Castagnolo, Matthew ToddWe outline major bottlenecks and the clinical pipeline landscape, then present a structure-led analysis of synthetic small-molecule validated leads supported by in vivo data.