Antiarthritic and Antinociceptive Properties of Ylang-Ylang (Cananga odorata) Essential Oil in Experimental Models
Paloma Kênia de Moraes Berenguel Lossavaro, Josyelen Lousada Felipe, Joyce dos Santos Lencina, Iluska Senna Bonfá, Kamylla Fernanda Souza de Souza, Lucas Luiz Machado, Mila Marluce Lima Fernandes, João Victor Ferreira, Maria Inês Lenz Souza, Luciane Candeloro, Cândida Aparecida Leite Kassuya, Edgar Julian Paredes-Gamero, Eduardo Benedetti Parisotto, Mônica Cristina Toffoli-Kadri, Saulo Euclides Silva-FilhoThe aim of this study was to evaluate the effect of ylang-ylang (Cananga odorata) essential oil (YEO) on models of experimental arthritis, persistent inflammation, and nociception in mice. YEO treatment at doses of 100 and 200 mg/kg reduced the infiltration of leukocytes into the joint cavities of mice submitted to zymosan-induced arthritis 6 h and 7 days after arthritis induction. At these doses, YEO treatment reduced the formation of joint edema 4 and 6 h after arthritis induction, and at a dose of 200 mg/kg, YEO treatment reduced mechanical hyperalgesia 3 and 4 h after arthritis induction. At the dose of 200 mg/kg, YEO treatment reduced interleukin-6 (IL-6) levels and cartilage destruction in the zymosan-induced arthritis model, and reduced edema formation and mechanical hyperalgesia in the model of persistent inflammation (21 days) induced by complete Freund’s adjuvant (CFA) in mice. YEO treatment at a dose of 200 mg/kg reduced the nociceptive response in experimental models of nociception induced by acetic acid and formalin. The YEO treatment reduced inflammatory parameters in the experimental arthritis model, and presented antiarthritic, anti-hyperalgesic, antinociceptive, and anti-inflammatory properties.