Anti-diabetic and Anti Microbial Activity of Pterocarpus Santalinus Heart Wood

Diabetes mellitus is a chronic illness, and the management of diabetes is a global problem. Successful treatment is required to prevent complications and organ damages. Herbal medicines are having minimal adverse effects when compared to the available synthetic drugs to treat such chronic diseases and disorders. The present study was aimed to evaluate the antidiabetic and antimicrobial activity of methanolic extract of Pterocarpus santalinus Heartwood. The in vitro antidiabetic activity of methanolic extract was evaluated in C2C12 cell lines by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (cell viability method) and glucose uptake assay. 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging method used for the evaluation of in vitro antioxidant activity. Methanolic extract of Pterocarpus santalinus Heartwood had shown better antimicrobial activity and cytotoxic activity in C2C12 cell line. From our study results, we concluded that Pterocarpus santalinus Heartwood had shown better antidiabetic activity and antimicrobial activity under in vitro models.