AngioNet: a systems biology approach to regulation of microvascular remodeling in response to skeletal muscle activity

We constructed exercise mode-specific angiogenic interaction networks (AngioNets) from endurance and resistance training human datasets. Overlapping stimulus-resolved rat transcriptomes onto these AngioNets, we showed that it is possible to promote angiogenesis through multiple stimuli, yet only a subset led to functional improvement. This divergence is explained by changes in local capillary supply, rather than gross capillary number. Across both human AngioNets, hub-set activity linked transcriptomic programs to microvascular structure, modeled tissue PO ₂ , and fatigue resistance.