Analysis of queries in an HIV drug–drug interaction checker to explore changes in prescribing patterns: A 5‐year analysis
Cecile Gras, Minh P. Le, Justin Chiong, Sara Gibbons, Daniel Seddon, Catia Marzolini, Saye KhooAims
Careful consideration of drug–drug interactions (DDIs) is critical as people with HIV age. We analysed queries submitted to the University of Liverpool HIV Drug Interactions Database to assess changes in prescribing patterns over 5 years.
Methods
Queries submitted between January 2020 and December 2024 were extracted and categorized by year, antiretroviral agent, comedication class, interaction severity (green/yellow/amber/red) and country. Descriptive statistics and annual trends were assessed.
Results
A total of 7 274 301 queries from 48 countries were recorded, representing a 441% increase over the study period. Dolutegravir (21%) and bictegravir (20%) were the most queried antiretrovirals, and queries involving unboosted integrase inhibitors rose. The most queried comedication classes were antibacterials, lipid‐lowering agents and supplements/vitamins. Amber and red DDIs declined by 6% and 3% between January 2020 and December 2024, while green increased by 9%.
Conclusions
Query volume rose markedly while DDI severity declined, likely reflecting broader use of modern antiretrovirals with more favourable interaction profiles. Continued vigilance and interaction‐checking tools remain essential in HIV care.