DOI: 10.4103/jdmimsu.jdmimsu_265_22 ISSN:

Analysis of Genome Wide Associated Variants rs2651899 (PRDM16), rs11172113 (LRP1), and rs10166942 (TRPM8) of Migraine in the Indian Episodic Migraineurs

Agaath Hedina Manickam, Sivasamy Ramasamy
  • General Medicine
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Background:

The involvement of genes in migraine pain is identified by several studies. Many genome-wide association studies (GWAS) revealed the presence of particular variants in different migraine populations worldwide.

Objective:

This study aims in analyzing the presence of 3 GWAS variants (rs2651899 [PRDM16], rs11172113 [LRP1], and rs10166942 Transient Receptor Potential Cation Channel Subfamily M Member 8 [TRPM8]) in the Indian episodic migraineurs.

Methodology:

Enrolled 200 age- and gender-matched patients and control volunteers; collected blood samples to isolate DNA to check the presence of chosen variants in them. The results obtained were statistically analyzed using SPSS version 26.0.

Results:

The rs10166942 (TRPM8) variant is observed in 1.5% of control, 15.88% of migraine with aura, and 5.37% of migraine without aura subjects with the highly significant P < 0.0008. The other two variants are absent in the chosen sample group.

Conclusion:

We reported the presence of rs10166942 in the Indian episodic migraineurs and we recommend pathway analysis for confirming its association with the migraine pain progression.

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