Anaphylaxis is the most important acute systemic allergic reaction. The incidence of anaphylaxis has been increasing in recent years. Therefore, all healthcare providers should know the diagnosis and management of anaphylaxis. In this article, the current approach to anaphylaxis is presented, considering the criteria accepted by the World Allergy Organization (WAO) and the European Academy of Allergy and Clinical Immunology (EACCI). Intramuscular epinephrine is the first-line treatment for anaphylaxis. However, it is still not used at the desired level. Children at risk of anaphylaxis should be trained to use adrenaline autoinjectors. After anaphylaxis develops, children should be referred to an allergist to investigate the underlying causes.