An Uncertainty-Aware Transformer–Fuzzy Framework for Parkinson’s Disease Detection Using Handwritten Motor Patterns

Parkinson’s disease is a progressive neurodegenerative disorder characterized by motor impairments that significantly affect handwriting and fine motor control. Recent advances in artificial intelligence have enabled the non-invasive analysis of handwritten patterns as reliable digital biomarkers for early Parkinson’s disease detection. However, existing deep-learning approaches often struggle with diagnostic uncertainty and lack interpretability, limiting their clinical reliability and practical adoption. Moreover, models trained on single datasets frequently exhibit poor generalization across heterogeneous handwriting sources. This study uses two image-based handwriting datasets and one CSV-based HandPD feature dataset, including the Parkinson’s Augmented Handwriting Dataset, Parkinson’s Drawings Dataset, and HandPD Spiral/Meander feature records. A Transformer-based architecture is employed to learn global motor patterns from handwriting images, followed by a fuzzy-logic-based decision layer to handle uncertainty and improve robustness. The novelty of this work lies in integrating Transformer-driven deep feature learning with fuzzy clinical reasoning, supported by an AIC-based handcrafted feature analysis for interpretability. The model performance is evaluated using accuracy, precision, recall, F1-score, MCC, and AUC metrics. The experimental results demonstrate that the proposed Transformer–Fuzzy framework consistently outperforms CNN and Transformer-only baselines, achieving superior classification performance and robust generalization across all datasets, thereby establishing its effectiveness for reliable and interpretable Parkinson’s disease screening.