DOI: 10.55262/fabadeczacilik.1479735 ISSN: 1300-4182

An Overview of Synthetic Derivatives of Thiazole and their Role in Therapeutics

Manoj Kashyap, Muslek Uddın Mazumder, Pooja Patowary, Apurba Talukdar, Bhargab Jyoti Sahariah, Manish Majumder
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Thiazole derivatives have attracted much attention in medicinal chemistry due to their diverse pharmacological activities. This study provides an overview of the latest synthetic derivatives of thiazole and their therapeutic applications. Innovative methodologies have been adopted to enhance the structural diversity and optimize the pharmacological properties of thiazole-based compounds. These synthetic derivatives exhibit a broad spectrum of therapeutic activities, and understanding the essential features responsible for the observed pharmacological effects has been pivotal in structure-activity relationship studies. Drug development efforts have focused on modulating thiazole derivatives for improved bioavailability, selectivity, and reduced toxicity. This abstract highlight the potential of thiazole derivatives in targeting specific biological activity, paving the way for developing innovative therapeutic agents. Thiazole moiety as a heterocyclic compound was studied for its different pharmacological actions. The derivatives obtained from thiazole possesses diverse therapeutic actions including antimicrobial activity, anti-tubercular activity, anti-diabetic activity, anti-convulsant, anti-inflammatory actions, anti-tumor activities. The mechanism of actions of all these activities also studied by the researcher for providing the scientific evidence and validations of their actions. Utilization of synthetic chemistry for exploration of various pharmacological potential of thiazole derivatives will lead the future pharmacologists for a newer dimension for new drug discovery and also these derivatives can be further optimized for the development of alternative option for the treatment of various diseases. The versatility of thiazole scaffolds presents promising opportunities for discovering new drugs with enhanced efficacy and improved pharmacokinetic profiles. As researchers continue to delve into the synthesis and pharmacological evaluation of thiazole derivatives, their significance in modern drug design and therapy becomes increasingly evident.

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