Rajendra Kumar Sharma, Sapna Gandhi, Mukta Meel, Anil Kumar Nehra, Tapendra Kumar Upadhay, Shrabani Barman

AN OBSERVATIONAL STUDY OF THE ROLE OF IMMUNOHISTOCHEMISTRY IN THE ANALYSIS OF MALIGNANT SMALL ROUND CELL TUMORS

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Background: Small round cell tumors (SRCT) are heterogeneous malignancies featuring primitive undifferentiated small cell morphology and describe the group of highly aggressive malignant tumors composed of relatively small and monotonous undifferentiated cells with increased nuclear-cytoplasmic ratio. Immunohistochemistry (IHC) has emerged as the most practical adjunct tool to histopathology making accurate diagnosis possible. To study the role of Immunohistochemistry in the analysis of ma Aim: Objectives:- lignant small round-cell tumors. (1) To study the importance of immunohistochemistry prole in malignant small round cell tumors. (2) Categorize the malignant small round cell tumors by Immunohistochemistry. (3)To know the age and sex incidence of malignant small round cell tumors. (4) To correlate histopathological and IHC features. Total 90 cases had been reported as Malignant Round Cell Tumor on biopsy.duri Materials and Methods: ng the study period 2021-22. Biopsy tissues/ samples were xed, parafn embedded, sectioned and, stained with hematoxylin and eosin. IHC was performed on each case. Results were analyzed and compared. Out of 90 cases, There were 31 cases(34.4%) of Results: Small Cell Carcinoma with the highest incidence, followed by 28 cases (31.1%) of Non-Hodgkin's lymphoma, Synovial Sarcoma 10 cases (11.1%), Ewings Sarcoma 8 cases(8.9%),Neuroblastoma 5 cases(5.6%), Malignant Melanoma 4 cases (4.4%), Rhabdomyosarcoma 3 cases(3.3%) and 1 case of Wilms Tumor. Malignant Conclusion :- Small Round Cell Tumors comprise a wide range of Heterogeneous group of Tumors. On light microscopy, these tumors have the basic morphologic themes of small round blue cells. In the diagnosis of Malignant small Round Cell Tumors, , light microscopic ndings is basic but not exact categorization done in many Undifferentiated Tumors. For diagnosis and exact categorization Immunohistochemistry are all taken into consideration. Immunohistochemical marker study has a great role of categorizing these tumors and accurate diagnosis is made possible which enable the patients to get the appropriate treatment and for better Prognosis

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