Background : The diagnosis and classication of AML were based on the French–American–British (FAB) system for nearly three decades. Morphological examinations of peripheral blood and bone marrow have consistently added value to this classication. Multiparameter ow cytometry is the preferred method of immunophenotypic analysis in AML due to the ability to analyze large numbers of cells in a relatively short period with simultaneous recording of information about several antigens for each cell. This observational type of cross Methods and Material : sectional study was carried out in the Pathology department, S.M.S. Medical College, Jaipur, during the period of 2021-2022. A total of 100 patients of all ages and both genders who were newly diagnosed with acute myeloid leukemia were included. Demographic data was noted. The samples were analysed for blast percentage and morphology on leishman stained peripheral blood and bone marrow smears. Immunophenotyping was done by ow cytometry. This included samples of peripheral blood or bone marrow aspirate from patients of morphologically diagnosed AML patients. Results : The most common subtype was AML- M2 and most commonly expressed antigen was CD33 followed by CD13.The mean positivity for CD33 among all AML subtypes was 98.94%. Aberrant expression of CD7 and CD19 were expressed in 5.32% and 4.26% of all cases respectively. There was concordance rate of 94% between morphology and FCM in our study. A combined eva Conclusion : luation of peripheral blood lm, bone marrow aspiration and ow cytometry were done. Flow cytometric analysis must always be performed in conjunction with cytomorphology for denitive diagnosis of acute myeloid leukemia.

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