DOI: 10.1039/d6nj02303g ISSN: 1144-0546
An irinotecan nanoprodrug self-assembled from small molecules for nitroreductase-responsive drug release
Xinxi Huang, Long Lin, Changyu Huang, Yongmei Jia, Guohua Zhou, Yuting Chen, Peilian Liu, Chenyue ZhanActive ester-mediated strategy yields nitroreductase-responsive irinotecan nanoprodrugs via small-molecule self-assembly, enabling carrier-free targeted delivery and on-demand release in hypoxic tumors with high selectivity.