An innovative course-based undergraduate research experience (CURE) in HPV-associated cervical cancer: integrating molecular oncology research and scientific writing in undergraduate education

Course-based undergraduate research experiences (CUREs) widen access to authentic research by embedding open-ended investigations into undergraduate curricula. Here, we describe a semester-long CURE in cancer biology that integrates molecular biology techniques, data analysis, and structured scientific writing within an upper-level undergraduate course. Students engaged in the study of HPV-associated cervical carcinogenesis by investigating the role of a candidate gene using siRNA-mediated knockdown and quantitative PCR (qPCR) analysis in cervical cancer cell lines. The primary aims of the course were to increase students’ conceptual understanding of molecular oncology and to develop proficiency in experimental design, primary literature interpretation, data analysis, and scientific communication. Analytical rubrics for laboratory performance, written reports, posters, and oral presentations were used to evaluate student learning, along with a post-course survey measuring perceived learning gains and research self-efficacy. All students successfully completed the experimental workflow and demonstrated increased confidence in molecular techniques, data analysis, and interpretation of scientific data. A distinctive feature of this CURE was the integration of structured scientific writing, which led to student co-authorship of a peer-reviewed review article, reinforcing the linkage between laboratory research and scholarly dissemination. Although implemented with a small cohort, this pilot study provides a scalable and adaptable model for incorporating clinically relevant research and scientific communication into undergraduate science education.