DOI: 10.1093/ofid/ofag498 ISSN: 2328-8957
An Exploratory Study of Host Plasma Proteomic Signatures that Distinguish Secondary and Early Latent Syphilis in Adults
Cody Chou, Shad R Morton, Kelika A Konda, Silver Vargas, Michael Reyes-Diaz, Francesca Vasquez, Carlos F Caceres, Jeffrey D Klausner, Trey Toombs, Rushdy Ahmad, Lao-Tzu Allan-BlitzAbstract
Syphilis diagnostics struggle to distinguish active from treated disease. Using tandem-mass-tag proteomics on plasma from 10 secondary and early latent syphilis cases and 8 matched controls, we identified 54 differentially regulated proteins categorized under several biological pathways. Those exploratory findings support proteomics as a tool for developing novel syphilis diagnostics.