An evaluation of the effectiveness of ‘ULTRACOL 200′ in enhancing nasolabial fold wrinkles through cutaneous repair
Nguyen Ngan Giang, Hyunjee Kim, Pham Ngoc Chien, Han Jin Kwon, Jung Ryul Ham, Won Ku Lee, Yeon Ju Gu, Shou Yi Zhou, Xin Rui Zhang, Sun Young Nam, Chan Yeong Heo- Dermatology
Abstract
Background
Injectable filler, a nonsurgical beauty method, has gained popularity in rejuvenating sagging skin. In this study, polydioxanone (PDO) was utilized as the main component of the ULTRACOL200 filler that helps stimulate collagenesis and provide skin radiant effects. The study aimed to evaluate and compare the effectiveness of ULTRACOL200 with other commercialized products in visually improving dermatological problems.
Methods
Herein, 31 participants aged between 20 and 59 years were enrolled in the study. 1 mL of the testing product, as well as the quantity for the compared groups was injected into each participants face side individually. Subsequently, skin texture and sunken volume of skin were measured using ANTERA 3D CS imaging technology at three periods: before the application, 4 weeks after the initial application, and 4 weeks after the 2nd application of ULTRACOL200.
Results
The final results of skin texture and wrinkle volume evaluation consistently demonstrated significant enhancement. Consequently, subjective questionnaires were provided to the participants to evaluate the efficacy of the testing product, illustrating satisfactory responses after the twice applications.
Conclusion
The investigation has contributed substantially to the comprehension of a PDO‐based filler (ULTRACOL200) for skin enhancement and provided profound insight for future clinical trials.