DOI: 10.1039/d6bm00447d ISSN: 2047-4830
An esterase-activated celastrol delivery system suppressed steatosis-related hepatocellular carcinoma progression
Zile Shao, Yangla Xie, Yidan Shen, Yiyang Sun, Long Zhang, Nasha Qiu, Xiao XuSchematic illustration of intratumorally delivered PQDMA@CEL NPs, triggering HCC ferroptosis and degrading lipids, and further remodeling immunosuppressive microenvironment and enhancing anti-tumor efficacy in Hepa1-6 bilateral tumor models.