Kasper Mikkelsen, Janine Zara Bowring, Yong Kai Ng, Frida Svanberg Frisinger, Julie Kjærsgaard Maglegaard, Qiuchun Li, Raphael N. Sieber, Andreas Petersen, Paal Skytt Andersen, Jakob T. Rostøl, Nina Molin Høyland-Kroghsbo, Hanne Ingmer

An Endogenous Staphylococcus aureus CRISPR-Cas System Limits Phage Proliferation and Is Efficiently Excised from the Genome as Part of the SCC mec Cassette

  • Infectious Diseases
  • Cell Biology
  • Microbiology (medical)
  • Genetics
  • General Immunology and Microbiology
  • Ecology
  • Physiology

CRISPR-Cas is an adaptive immune system protecting bacteria and archaea against mobile genetic elements such as phages. In strains of Staphylococcus aureus , CRISPR-Cas is rare, but when present, it is located within the SCC mec element, which encodes resistance to methicillin and other β-lactam antibiotics.

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