An All‐in‐One Nanoplatform for Synergistic Anti‐Infection and Healing of Diabetic Wounds via Photothermal‐Gas Therapy

ABSTRACT

Diabetic wounds represent a significant clinical challenge, characterized by bacterial biofilm formation, persistent inflammation, and oxidative stress. Although photothermal therapy (PTT) and gas therapy (e.g., CO, H ₂ ) are promising alternatives to conventional antibiotics, existing monotherapeutic strategies fail to address the multifactorial pathological characteristics of these wounds, which is a critical research gap. To fill this gap, an integrated multimodal nanoplatform (CO/AB@MPDA) by co‐loading dodecacarbonyltriiron (FeCO, a CO donor) and ammonia borane (AB, a H ₂ donor) into mesoporous polydopamine (MPDA) carriers was developed. The innovation lied in its synergistic design. It enabled near‐infrared (NIR)‐triggered CO release and pH‐responsive H ₂ generation, simultaneously targeting infections, inflammation, and microenvironment dysregulation. In vitro and in vivo experiments confirmed its potent antibacterial/biofilm‐disrupting activity, high biosafety, reactive oxygen species (ROS) scavenging, anti‐inflammatory properties, as well as superior ability to accelerate diabetic infected wound healing. In summary, the CO/AB@MPDA nanosystem overcomes the limitations of monomodal therapies through synergistic PTT‐gas therapy, providing an innovative and comprehensive therapeutic strategy for diabetic wound infections.