Outline
DOI: 10.1039/d6ra08498b ISSN: 2046-2069
An activator-free method for the synthesis of nucleotide 5′–5′ triphosphate mRNA capping agent
Eric Tam, Viktor Barát, Tzuen Yih Saw, Kuo-Chieh Liao, Yue Wan, Shuwen Chen, Ying Swan Ho, Yee Hwee LimA metal salt-free synthesis of nucleotide 5′–5′ triphosphates such as Anti-Reverse Cap Analog (ARCA) is achieved by modulating the solubility and reactivity of the monophosphate coupling partner using an ionic liquid and a novel paired cation.
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