Alzheimer's disease polygenic risk scores and postoperative delirium: A promising marker, but not yet a clinical tool

Recent advances in Alzheimer's disease (AD) biomarkers and genomics have raised interest in personalized approaches to related conditions such as postoperative delirium (POD). Chen et al. report a moderate association between AD polygenic risk scores (AD-PRS) and POD, suggesting genetic susceptibility as a marker of biological vulnerability. However, the clinical utility of AD-PRS remains uncertain, as the study does not demonstrate incremental predictive value over established clinical risk factors. At present, AD-PRS should be considered a research tool. Future studies should assess its predictive performance, cost-effectiveness, and ethical implementation in diverse populations.