AbstractAlcoholic liver disease (ALD), which is a leading cause of morbidity and mortality worldwide, covers a large spectrum of liver injuries ranging from simple steatosis to steatohepatitis, advanced fibrosis, cirrhosis, and hepatocellular carcinoma. The pathogenesis of ALD includes genetic and epigenetic alterations, oxidative stress, acetaldehyde‐mediated toxicity and cytokine and chemokine‐induced inflammation, metabolic reprogramming, immune damage, and dysbiosis of the gut microbiota. This review discusses the progress in the pathogenesis and molecular mechanism of ALD, which could provide evidence for further research on the potential therapeutic strategies targeting these pathways.

More from our Archive

• DOI: 10.1111/apt.17622 2023

  Review article: Translating STRIDE‐II into clinical reality – Opportunities and challenges

  Axel Dignass, Stefan Rath, Thomas Kleindienst, Andreas Stallmach

• DOI: 10.14309/ajg.0000000000002340 2023

  Acute Liver Failure Guidelines

  Alexandra Shingina, Nizar Mukhtar, Jamilé Wakim-Fleming, Saleh Alqahtani, Robert J. Wong, Berkeley N. Limketkai, Anne M. Larson, Lafaine Grant

• DOI: 10.1111/apt.17637 2023

  Clinical utility of liver fat quantification for determining cardiovascular disease risk among patients with type 2 diabetes

  Selena Z. Kuo, Sandra Cepin, Jaclyn Bergstrom, Harris Siddiqi, Jinho Jung, Scarlett Lopez, Daniel Q. Huang, Pam Taub, Maral Amangurbanova, Rohit Loomba

• DOI: 10.1111/apt.17631 2023

  Effects of social determinants of health on mortality and incident liver‐related events and cardiovascular disease in steatotic liver disease

  Vincent L. Chen, Michael W. Song, Deepika Suresh, Sharad I. Wadhwani, Ponni Perumalswami

• DOI: 10.1093/ecco-jcc/jjad115 2023

  Upadacitinib Salvage Therapy for Infliximab-Experienced Patients with Acute Severe Ulcerative Colitis

  Robert Gilmore, Wei Lian Tan, Richard Fernandes, Yoon-Kyo An, Jakob Begun

• DOI: 10.1097/meg.0000000000002592 2023

  Transjugular intrahepatic portosystemic shunt insertion improves muscle mass but not muscle function or frailty measures

  Penelope Hey, Brooke Chapman, Darren Wong, Paul Gow, Adam Testro, Ryma Terbah, Marie Sinclair

• DOI: 10.1111/apt.17629 2023

  Detection of changes in regional colonic fermentation in response to supplementing a low FODMAP diet with dietary fibres by hydrogen concentrations, but not by luminal pH

  Daniel So, Chu K. Yao, Paul A. Gill, Phoebe A. Thwaites, Zaid S. Ardalan, Chris S. McSweeney, Stuart E. Denman, Adam F. Chrimes, Jane G. Muir, Kyle J. Berean, Kourosh Kalantar‐Zadeh, Peter R. Gibson

• DOI: 10.1111/hel.13007 2023

  <scp>TikTok</scp> and Bilibili as sources of information on <i>Helicobacter pylori</i> in China: A content and quality analysis

  Ren‐Chun Du, Yang Zhang, Meng‐Hui Wang, Nong‐Hua Lu, Yi Hu

• DOI: 10.14309/ctg.0000000000000621 2023

  Drug-Induced Acute Pancreatitis: An Evidence-Based Classification (Revised)

  Jasmine Saini, Daniel Marino, Nison Badalov, Melanie Vugelman, Scott Tenner

• DOI: 10.1111/jgh.16272 2023

  AMPK/mTOR pathway significance in healthy liver and non‐alcoholic fatty liver disease and its progression

  Ilitch Aquino Marcondes‐de‐Castro, Pedro Henrique Reis‐Barbosa, Thatiany Souza Marinho, Marcia Barbosa Aguila, Carlos Alberto Mandarim‐de‐Lacerda