Age- and sex-specific differences in sympathetic vascular transduction and neuro-hemodynamic balance in humans

Bursts of muscle sympathetic nerve activity (MSNA) and the ensuing vasoconstriction are pivotal determinants of beat-by-beat blood pressure regulation. Although age and sex impact blood pressure regulation, how these factors affect the central and peripheral arcs of the baroreflex remains unclear. In 27 young (25[3] years) males (YM; n=14) and females (YF; n=13) and 23 older (71[5] years) males (OM; n=11) and females (OF; n=12) femoral artery blood flow, blood pressure and MSNA were recorded for 10 minutes of supine rest. Sympathetic baroreflex sensitivity (i.e., central arc) was quantified as the relationship between diastolic blood pressure and MSNA burst incidence. Signal averaging was used to determine sympathetic vascular transduction into leg vascular conductance (LVC) for 12 cardiac cycles following MSNA bursts (i.e., peripheral arc). Older adults demonstrated attenuated sympathetic transduction into LVC (both P<0.001) following MSNA bursts, and smaller increases in sympathetic transduction as a function of MSNA burst size and firing pattern compared to young adults (range: P=0.004-0.032). YM (r²=0.36; P=0.032) and OM (r²=0.51; P=0.014) exhibited an inverse relationship between the central and peripheral arcs of the baroreflex, whereas females did not (YF: r²=0.03; P=0.621, OF: r²=0.06; P=0.445). MSNA burst incidence was inversely related with sympathetic transduction in YM and OF (range: P=0.03-0.046), but not in YF or OM (range: P=0.360-0.603). These data indicate that age is associated with attenuated sympathetic vascular transduction whereas age- and sex-specific changes are present in the relationship between the central and peripheral arcs of the baroreflex regulation of blood pressure.