Adverse Pregnancy Outcomes and Early Prediction of Cardiovascular Disease Risk: Vascular and Inflammatory Markers
Leah Spiro, Eynav E. Accortt, Sarah Kilpatrick, Judith E. Carroll, Galen Cook Wiens, C. Noel Bairey Merz, Margo B. MinissianBackground:
Women with adverse pregnancy outcomes (APOs) have a 2- to 8-fold increased risk of future atherosclerotic cardiovascular disease (ASCVD), yet the mechanistic pathways are not well-defined. Potential vascular and inflammatory factors contributing to ASCVD are not known in women with a history of preeclampsia (PE) or spontaneous preterm delivery (sPTD).
Objective:
Describe the vascular and inflammatory factors of women with PE or sPTD and compare differences that may contribute to ASCVD risk.
Methods:
Women 18 years or older, 2–3 years postpartum, with a history of PE (
Results:
Participants with sPTD had higher interleukin-8 concentrations of 6.6 pg/mL (interquartile range [IQR] 5.7, 8.7), compared with 4.7 pg/mL (IQR 2.2, 6.3) in controls (
Conclusions:
Vascular and inflammatory markers in PE or sPTD 2–3 years postpartum are higher compared with reference controls. Future studies should investigate vascular and inflammatory function in larger cohorts and prospectively evaluate contribution to CVD risk.