DOI: 10.11648/j.bs.20261202.12 ISSN: 2575-3932

Advances in Vitamin D for the Treatment of Osteoporosis: A Review

Wenbin Sun, Haixiao Chen
Show PDF Cite
This review systematically summarizes the latest research progress of vitamin D in the clinical treatment of osteoporosis to consolidate available evidence for its clinical practice, combined medication schemes and relevant mechanisms linked to adipokines, so as to provide valuable references for clinical medication and further scientific exploration of osteoporosis. Literature retrieval was performed across authoritative databases including PubMed and CNKI, covering research articles published in recent years before August 26, 2025. All eligible retrieved documents were managed, classified and screened via EndNote reference management software. The incorporated studies concentrate on three core dimensions: clinical efficacy observation of vitamin D monotherapy, diverse combination therapies with anti-osteoporotic agents, and the regulatory relationship between vitamin D and multiple adipokines secreted by adipose tissue. Existing research confirms that vitamin D possesses tremendous research and clinical application potential in osteoporosis intervention. Over recent years, abundant clinical trials and basic researches have made continuous explorations and innovative breakthroughs regarding its practical clinical performance, rational combined administration principles and adipokine-mediated bone metabolism pathways. These emerging findings have greatly expanded the applicable scenarios of vitamin D and further improved its clinical value in osteoporosis prevention and treatment. In summary, by sorting out cutting-edge research data, this paper integrates updated research conclusions on vitamin D against osteoporosis. It not only helps clinicians formulate more individualized and standardized therapeutic regimens in daily practice, but also lays a solid theoretical foundation for subsequent basic researches and clinical trials targeting vitamin D, bone metabolism and adipokine network regulation.

More from our Archive