DOI: 10.1128/mmbr.00042-23 ISSN: 1092-2172

Advances in the cellular biology, biochemistry, and molecular biology of acidocalcisomes

Roberto Docampo
  • Molecular Biology
  • Microbiology
  • Infectious Diseases


Acidocalcisomes are organelles conserved during evolution and closely related to the so-called volutin granules of bacteria and archaea, to the acidocalcisome-like vacuoles of yeasts, and to the lysosome-related organelles of animal species. All these organelles have in common their acidity and high content of polyphosphate and calcium. They are characterized by a variety of functions from storage of phosphorus and calcium to roles in Ca 2+ signaling, osmoregulation, blood coagulation, and inflammation. They interact with other organelles through membrane contact sites or by fusion, and have several enzymes, pumps, transporters, and channels.

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