Advances in Chemical Peeling: Emerging Agents in Dermatology Practice

Abstract

Chemical peeling has long been an important procedure in dermatology for treating photoaging, pigmentary diseases, acne, and superficial scars. While traditional treatments such as glycolic acid, trichloroacetic acid, and salicylic acid have received substantial research, recent advances have broadened the arsenal with innovative compounds that promise greater effectiveness, tolerability, and personalized therapeutic results. This review seeks to offer a complete overview of the latest chemical peeling agents in dermatology, with an emphasis on their processes, clinical uses, benefits over conventional peels, and current information on safety and efficacy. Newer agents, such as lactic acid, phytic acid, mandelic acid, ferulic acid, and retinoic acid peels, along with combination systems, have shown promise in treating pigmentation disorders, sensitive skin conditions, and resistant acne while minimizing postinflammatory hyperpigmentation. Furthermore, bioengineered formulations and synergistic combinations provide customizable therapy alternatives. However, most data come from small-scale investigations, and big randomized controlled trials are few. Emerging chemical peeling agents offer a substantial development in dermatological therapy by expanding therapeutic indications, improving patient acceptability, and lowering consequences. Future research should attempt to standardize techniques and long-term results, making them easier to incorporate into ordinary clinical practice.