DOI: 10.2217/fon-2023-0365 ISSN: 1479-6694

Advances in breast cancer risk modeling: integrating clinics, imaging, pathology and artificial intelligence for personalized risk assessment

Filippo Pesapane, Ottavia Battaglia, Giuseppe Pellegrino, Elisa Mangione, Salvatore Petitto, Eliza Del Fiol Manna, Laura Cazzaniga, Luca Nicosia, Matteo Lazzeroni, Giovanni Corso, Nicola Fusco, Enrico Cassano
  • Cancer Research
  • Oncology
  • General Medicine

Breast cancer risk models represent the likelihood of developing breast cancer based on risk factors. They enable personalized interventions to improve screening programs. Radiologists identify mammographic density as a significant risk factor and test new imaging techniques. Pathologists provide data for risk assessment. Clinicians conduct individual risk assessments and adopt prevention strategies for high-risk subjects. Tumor genetic testing guides personalized screening and treatment decisions. Artificial intelligence in mammography integrates imaging, clinical, genetic and pathological data to develop risk models. Emerging imaging technologies, genetic testing and molecular profiling improve risk model accuracy. The complexity of the disease, limited data availability and model inputs are discussed. A multidisciplinary approach is essential for earlier detection and improved outcomes.

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