DOI: 10.2174/0124681873339038241211164519 ISSN: 2468-1873

Advancements in Nanostructured Lipid Carriers and its Patent Innovations

Ashish S. Mishra, Shikha Sharma, Payal Bhatnagar, Bimal Krishna Banik

Abstract:

Nanostructured lipid carriers (NLCs) are small colloidal systems designed for drug delivery, recognized for their safety, biocompatibility, and non-toxicity. As a lipid-based nanosystem, NLCs offer a promising alternative to polymeric and metallic nanoparticles, providing a safe and effective platform for therapeutic applications. Their appeal lies in high stability, substantial drug loading capacity, and ability to enhance drug solubility and permeability. Encapsulation in a lipidic shell further aids in navigating challenging drug delivery routes, enhancing the bioavailability and stability of encapsulated drugs. Surface modifications and the incorporation of specific additives into NLCs allow for targeted drug delivery, increased cellular uptake, and prolonged residence time in the body, improving the therapeutic effect of the drugs administered. Due to these advantages, NLCs have demonstrated potential in treating a variety of medical conditions, including cancer, infections, neurodegenerative diseases, hypertension, diabetes, and pain management. This review explores recent advancements in the development and optimization of NLCs, highlighting their role in achieving efficient, targeted, and controlled drug delivery.

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