Adaptive Treatment for Youth with Co-occurring Substance Use and Depression: Long-term Outcome
Y. KaminerIntroduction
Co-occurring youth substance use and depression are common. The literature on treatment of this dual diagnosis that increase the likelihood of suicidal behavior is meager.
Objectives
To investigate the long-term outcomes among youth with substance use and depression, who enrolled in the Treatment for Teens with Alcohol Abuse and Depression (T-TAAD, Curry J., Kaminer Y., et al. JAACAP, 2022) study. First, identify predictors for end of treatment outcomes. Second, compare trajectories of outcomes from baseline to 9 months post end-of- treatment (EOT) across study arms: early depression responders (EDR), and non-EDR randomized into either cognitive behavioral therapy or enhanced treatment as usual.
Methods
All treatment participants (n=95) aged 14-21 years (Mean 17.4; SD=1.8) were invited to participate in three quarterly post EOT of a 14-week treatment period. Multiple imputation logistic regression models were used to identify predictors of three outcomes: depression remission, alcohol and cannabis abstinence. The long-term trajectory covers seven assessment timepoints: baseline, four, nine, and 14 weeks. Also, three, six-, and nine-months post EOT. Mixed-effect and generalized mixed-effect models were used to examine the trajectories of the following outcomes: The Children’s Depression Rating Scale (CDRS-R) total score, alcohol use and heavy use frequencies, cannabis using days, cannabis urine test, the Children’s Global Assessment Scale (CGAS) score, and Suicide Ideation Questionnaire-Junior (SIQ-JR) score.
Results
All treatment participants (n=95) aged 14-21 years (Mean 17.4; SD=1.8) were invited to participate in three quarterly post EOT of a 14-week treatment period. Multiple imputation logistic regression models were used to identify predictors of three outcomes: depression remission, alcohol and cannabis abstinence. The long-term trajectory covers seven assessment timepoints: baseline, four, nine, and 14 weeks. Also, three, six-, and nine-months post EOT. Mixed-effect and generalized mixed-effect models were used to examine the trajectories of the following outcomes: The Children’s Depression Rating Scale (CDRS-R) total score, alcohol use and heavy use frequencies, cannabis using days, cannabis urine test, the Children’s Global Assessment Scale (CGAS) score, and Suicide Ideation Questionnaire-Junior (SIQ-JR) score.
Conclusions
Youth who responded early (EDR), had better substance use, depression and functioning long-term outcomes than the non-EDR.
Disclosure of Interest
None Declared