DOI: 10.1021/acs.orglett.6c02896 ISSN: 1523-7060
Acylation of N -Heteroarenes with Aldehydes Catalyzed by Photoexcited Hydrogen Chloride in Acetonitrile
Yuwei Wang, Menghui Yu, Naibei Hou, Yingchang Guo, Fan Yang, Jialiang Zhang, Xinqiang Tan, Lizhen FangAbstract
Using inexpensive HCl as the only catalyst in acetonitrile, a photoinduced acylation of six kinds of N-heteroarenes with aromatic and aliphatic aldehydes was developed. This protocol features facile operation, short reaction times, mild reaction conditions, and a broad substrate scope, providing efficient access to diverse acylated N-heterocyclic compounds.