DOI: 10.1039/d6tb01437b ISSN: 2050-750X
Acellular matrix microgel assembly integrated with curcumin-loaded ZIF-8 nanoparticles and simvastatin promotes microfracture-based articular cartilage repair via pyroptosis inhibition, endogenous BMSC r
Junlin Chen, Qingtao Li, Chuhan Lv, Hongbo Yu, Zibo Liu, Hua DongThis study reports an acellular cartilage matrix microgel assembly. After injection, SIM recruits microfracture-derived BMSCs, while Cur released from ZIF-8 inhibits pyroptosis, synergistically promoting hyaline cartilage regeneration.