Abstract WP115: Patient Reported Outcomes to Improve the Accuracy of Disability Evaluation After Endovascular Treatment-Successful Recanalization
Federica Rizzo, Marta Olivé-Gadea, Manuel Requena, Marc Rodrigo-Gisbert, Maria Belen Taborda, Marian Muchada, Pere Canals, Jesus Juega, Jorge Pagola, David Rodriguez-Luna, Noelia Rodriguez-Villatoro, Alvaro Garcia-Tornel, Giorgio Colangelo, Jordi Brunet, Carolina-Kina Paredes, Ester Sanchez, Cristina Guirao, Maria Baladas, Marta De Dios Lascuevas, Francesco Diana, David Hernandez, Alejandro Tomasello, Carlos Molina, Marc Ribo, Marta Rubiera- Advanced and Specialized Nursing
- Cardiology and Cardiovascular Medicine
- Neurology (clinical)
Background: Complete recanalization is a well-known predictor of functional outcome among patients who undergo MT. However, trying to improve recanalization from successful (eTICI ≥ 2b) to complete (eTICI2c-3) with more passes is under debate. PROMS allow an accurate assessment of patients status in different domains after AIS.
Hypothesis: In AIS patients undergoing MT, PROMS may allow a more precise characterization of the long-term outcome than the usual mRS according to different degrees of recanalization.
Methods: Patients with anterior circulation AIS, treated with MT who achieved a successful recanalization (eTICI ≥ 2b) were included. Patients were classified in two groups according to the degree of recanalization: eTICI 2b (successful) vs eTICI 2c-3 (complete). The collected study variables were baseline, procedural characteristics, and 90 days outcome measures including: assessment of disability by a certified clinician blinded to recanalization status (mRS) and PROMS (PROMIS 10- Physical and Mental, HAD depression and Anxiety, visual EQ-5D scale)
Results: From Jan 2020 to Dec 2022, 96 patients with PROMS collection at 90 days were identified: 21 had a final eTICI 2b and 75 a final eTICI2c-3. No differences in terms of age, sex and other baseline and procedural characteristic were observed between groups. Median 90-days mRS was similar in both groups (2 [IQR 1-3]; p= 0.517). At 90 days patients achieving TICI 2c-3 had significantly lower HAD depression score: 7 [3-10] vs 10 [7-15] (p=0.02). All other median PROMS values were numerically favourable for patients who achieved TICI 2c-3: visual EQ-5D scale: 64 [10-80] vs 50 [42-65] (p= 0.1), PROMIS 10-Physical and Mental (eTICI 2b: 12 [10-14] and 12 [9-15] versus eTICI 2c-3: 9[7-12] and 9 [7-12]; p=0.8 and p=0.6 respectively), except for HAD-anxiety score (eTICI 2b: 6 [3-9] versus eTICI 2c-3: 7 [4-9]), p=0.520). More than 250 patients will complete the 90 days follow-up in the next 6 months, analyses will be updated for presentation at the conference
Conclusion: The differences observed between patients achieving successful versus complete recanalization indicate that PROMs may be more adequate tool than the usual mRS for a fine-tune characterization of long-term outcome in different quality of life domains