Abstract 412: Targeted Temperature Management for Patients With Out of Hospital Cardiac Arrest: A Comparison of the TTM2 Trial Population With Real World Data

Introduction: The TTM2 trial demonstrated no improvement of the functional status in survivors of Out-of-Hospital Cardiac Arrest (OHCA). However, the external validitiy of the trial remains to be investigated.

Aim: We aimed to compare the patient population of the TTM2 trial to the real world data.

Methods: We obtained the data from multiple national registries including Cardiac Arrest Registry to Enhance Survival (CARES), the Australasian Resuscitation Outcomes Consortium (Aus-ROC), the Danish Cardiac Arrest Registry (DCAR), and the Swedish Cardiopulmonary Resuscitation Registry (SCRR). We pooled the data from these registries and compared them to the data from the TTM2 trial.

Results: We identified a total of 262,482 encounters from all the databases and 1,861 encounters from the TTM2 trial. The average age was comparable between both groups (64 years), females gender (registries 35% vs trial 20%), arrest event happened at the place of residence (registries 72% vs trial 53%), Bystander-witnessed arrest (registries 57% vs trial 91%), Bystander-performed CPR (registries 38% vs trial 80%), initial shockable rhythm (registries 25% vs trial 74%), non-shockable rhythm (registries 75% vs trial 26%).

Conclusion: Large discrepancies were identified between the data from the TTM2 and the pooled data obtained from multiple registries. This needs to be further investigated.