Abstract 19203: Predictors of Mortality Among Patients Admitted With Both Acute Myocardial Infarction and Non-Alcoholic Fatty Liver Disease

Introduction: Non-alcoholic fatty liver disease (NAFLD) is associated with an increased risk of cardiovascular disease (CVD). Indeed, cardiovascular disease is the most common cause of death among NAFLD patients We aimed to assess the association between NAFLD and mortality due to acute myocardial infarction and the predictors of in-hospital mortality among patients with both diagnosis in the USA.

Methods: Hospitalizations with AMI with a concurrent diagnosis of NAFLD were identified in the National Inpatient Sample (2016-2019) using ICD-10 codes. The prevalence and trends over four years were calculated among different sociodemographic groups. Regression model was used to determine mortality outcomes due to AMI among NAFLD patients by age, race, and gender. A multivariable regression analysis was done to determine NAFLD as an independent predictor of mortality.

Results: A total of 5450 patients were hospitalized with concurrent diagnosis of AMI and NAFLD during the study period. Among them, 5.11% (279) died in the hospital. Males were more likely to die compared to the females [OR 1.58, 95% CI 1.25-1.91]. Also, patients > 50 had higher odds of dying due to AMI if they had NAFLD compared to those <50 [OR 4.29, 95% CI 2.94-6.27]. Compared with the white population, Blacks [OR 0.79, 95% CI 0.54-1.15, p <0.001] Hispanics [OR 1.21, 95% CI 0.85-1.74, p <0.001], Asian and Pacific Islanders [OR 0.95, 95% CI 0.45-2.03, p <0.001], and Native Americans [OR 0.58, 95% CI 0.08-4.17, p <0.001] are less likely to die due to AMI if they have NAFLD. The NAFLD patients had higher odds of dying if they were admitted to the hospital with AMI [OR 1.96, 95% CI 1.74-2.21, p <0.001].

Conclusion: Elderly white males with NAFLD are more likely to die if they are admitted to the hospital due to AMI. NAFLD was found to be an independent predictor of death among patients who had AMI.