DOI: 10.1161/circ.148.suppl_1.17938 ISSN: 0009-7322

Abstract 17938: Identifying the Prevalence of Coronary Artery Disease Among Patients With Non-Alcoholic Fatty Liver Disease in the Adult US Population

Yelena Pleshkova, Alexia Sawyer, Chad Brands, Urvish Patel, Nishad Barve, Anusha Kavarthapu, Darshi Desai, Aditya Desai, Parth Shah, chandu siripuram, Deep Mehta, Mohammad Parvez
  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Introduction/Background: In the twenty-first century, new findings have helped unravel the outstanding significance of contributory roles of the different pathologies in the proper regulation of physiologic and metabolic homeostasis. NAFLD is presently considered one of the emerging gastroenterological pathologies in the world. In our research study, we describe the contributory potential of NAFLD to cardiovascular disease. We also examined the patterns of NAFLD and identified specific emerging subgroups to improve our understanding of intertwined mechanisms between NAFLD and the pathogenesis of systemic atherosclerotic diseases.

Aims and Objective: The primary outcome of the study was to identify the prevalence of NAFLD. The secondary outcome was to evaluate the prevalence of CAD in people with NAFLD and to describe the association between these two processes.

Methods: We performed a retrospective cross-sectional study using the National Health and Nutrition Examination Survey (NHANES) database from 2015 to 2018. Adults with a secondary diagnosis of NAFLD were identified. Univariate analysis was performed using Mann Whitney U test and chi-square test. A multivariable logistic regression analysis was performed to describe the association between NAFLD and CAD.

Results: Among a total of 275,968 people in this selected NHANES cohort, 0.26 were identified to have NAFLD. In the cohort, NAFLD was more prevalent in older (median: 62 years), males, Mexican Americans and Hispanics, and people with median household income >$100,000. People with NAFLD had an early onset of CAD (47 vs 60 years) with higher prevalence of CAD in NAFLD compared to the group without NAFLD (15.90% vs 4.64%). People with NAFLD had a significantly higher association of having CAD (prevalence odds: 9.78 [95% CI: 9.76-9.80]).

Conclusion: In a select NHANES cohort, positive correlations were identified between groups with NAFLD and the early onset of CAD. Additional findings include positive correlations for ethnicity, social economic status, and gender. Prospective studies and long-term clinical follow-up will be required to further characterize specific populations with NAFLD in an attempt to mitigate the burden of CAD within the population of NAFLD patients.

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