Abstract 17214: Sex Difference in Outcomes of Redo-Surgical Aortic Valve Replacement (redo-SAVR) for Failed Bioprosthetic Aortic Valves: Insights From the National Inpatient Sample

Introduction: Redo surgical aortic valve replacement (SAVR) remains the gold standard for the management of failed bioprosthetic valves (BV). We aim to determine if there are sex differences in in-hospital outcomes among patients who underwent redo-SAVR for failed BV.

Methods: We obtained the data from the National Inpatient Sample from 2013-2020. Our primary outcome was in-hospital mortality. Secondary outcomes included acute stroke, acute myocardial infarction (MI), acute kidney injury post-operative bleeding and blood transfusion. (See figure 1). Multivariable regression analyses were done to adjust for confounders.

Results: There were more men who underwent the procedure compared to women. (62.3% versus 37.7%, p<0.001) Hypertension, coronary artery disease and smoking were commonly seen among men. Obesity is more common among women. There was no difference in in-hospital mortality. Men were less likely than women to have vascular complications (adjusted odd ratio (aOR) 0.63, p<0.005; acute kidney injury aOR 0.63, p< 0.01, and acute stroke (aOR 0.6, p< 0.002).

Conclusions: Men underwent more redo-SAVR procedures than women. There were no sex difference in in-hospital outcomes, however, men were less likely to have AKI, stroke and vascular complications from the procedure. Further research is needed to explore these sex disparities.