Abstract 16496: Future Hypertension Risk Among a Peripartum Cardiomyopathy Cohort From Kaiser Permanente Northern California

Introduction: Women have unique sex-specific risk factors related to pregnancy and reproduction that are increasingly recognized as risk-enhancing factors for atherosclerotic cardiovascular disease (ASCVD). While studies have established hypertensive disorders of pregnancy as a risk factor for long-term maternal CVD and mortality, the long-term cardiovascular sequelae following peripartum cardiomyopathy (PPCM) are not as well established.

Aims: To determine whether the occurrence of PPCM increases later risk of hypertension.

Methods: Retrospective case-control study of pregnant patients identified within a Kaiser Permanente Northern California (KPNC) cohort of women with and without peripartum cardiomyopathy between 1998-2004, with up to 23 years follow up.

Results: We identified 62 PPCM cases, matched by age, delivery year, gestational age, pre-existing hypertension, hypertensive disorders of pregnancy, and hyperlipidemia to a control group of women without PPCM (Table 1). There was a statistically significant greater odds of incident essential hypertension among those with PPCM, 58.1% compared to 20.4% of matched controls, OR 5.39 (95%CI: 2.9, 10.02) at a mean 11 years of follow-up.

Conclusion: In the KPNC cohort, PPCM was a predictor for the development of essential hypertension later in life.*P<0.0001Table 1. Baseline demographic and cardiovascular risk factors for women with peripartum cardiomyopathy compared to a matched cohort. Unless otherwise specified, numbers shown represent frequency (percentage of total).