Abstract 15595: In-Hospital Outcomes in Patients With Psoriasis Who Undergo Transcatheter Aortic Valve Replacement

Background Psoriasis is a chronic inflammatory condition associated with an increased prevalence of aortic stenosis (AS). There is paucity of evidence regarding transcatheter aortic valve replacement (TAVR) outcomes in patients with psoriasis.

Methods: The National Inpatient Sample Database was queried from 2016-2019 for relevant ICD-10 diagnostic and procedural codes. Beeline characteristics and in-hospital TAVR outcomes were compared in patients with and without psoriasis. Multivariate logistic regression was performed for select outcomes to adjust for differences in baseline characteristics. A p value <0.05 was considered significant.

Results: 227,920 hospitalizations for TAVR were identified of which 1,510 (0.6%) were patients with psoriasis. See Table 1 for baseline characteristics. Patients with psoriasis were more likely to be white, and have concurrent diagnoses of hypertension, diabetes mellitus, hyperlipidemia, coronary artery disease, obesity, tobacco use disorder, COPD, and thrombocytopenia. Adjusting for baseline characteristics, those with psoriasis were found to have higher rates of in-hospital all-cause mortality OR 2.20 [1.57-3.09], and major bleeding events OR 1.38 [1.13-1.69].

Conclusions: Psoriasis is associated with worse outcomes and higher in-hospital mortality in TAVR. Further studies are warranted to optimize outcomes in this higher risk cohort.

Table 1. Patient Characteristics. Values are reported as mean ± standard deviation or median [interquartile range] for continuous variables. Categorical variables are represented as n (%). Between-group comparisons were performed for continuous data using T-test for parametric and Mann-Whitney U test for nonparametric variables, respectively. Categorical variables were compared using Chi squared test. A p-value <0.05 was considered significant (bold).