DOI: 10.1161/circ.148.suppl_1.15099 ISSN: 0009-7322

Abstract 15099: Sex Disparities in Patients With Cardiac Sarcoidosis Undergoing Implantable Cardioverter-Defibrillators Implantation in the United States

Raheel Ahmed, Kamleshun Ramphul, Ali Hasan, Muzammil Farhan, Azeem Hassan, Hasan Ahmad, Joseph Okafor, Caleb Carver, Taimurzeb Durrani, Ayesha Jadoon, Khadija Amanullah, Yumna Jamil, Maham Bilal, Sajeel Ahmed, Rahat A Memon, Hemamalini Sakthivel
  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Introduction: In patients with cardiac sarcoidosis (CS), implantable cardioverter-defibrillators (ICDs) are utilized to avoid sudden cardiac death. We aimed to compare the sex disparities in CS patients undergoing ICD implantation.Hypothesis:Higher ICD implantation would be observed in male CS patients as compared to females.

Methods: Males and females with CS receiving ICD were identified and compared from the 2016-2020 National Inpatient Sample (NIS) database whilst adjusting for confounders via logistic regression models.

Results: Of the 760 cardiac sarcoidosis patients undergoing ICD implantation, 505 (66.4%) were males and 255 (33.6%) were females. Around 94.1% of all procedures (715 cases) were conducted in urban teaching centres. In comparison to females, males were younger (55.0 vs 56.9 years, p<0.01) with higher prevalence of diabetes (31.7% vs 21.6% p<0.01) and chronic kidney disease (CKD) (16.8% vs 7.8% p<0.01) and a lower occurrence of reported depression (5.0 vs 19.6 p<0.01). Atrial fibrillation (AF) (23.5% vs 11.9%, p<0.01), sick sinus syndrome (SSS) (7.8% vs 4.0%, p=0.024) and ventricular fibrillation (VF) (15.7% vs 9.9%, p=0.02) were more prevalent in female CS receiving ICD. The percentages of ICD use in those with a history of hypertension, smoking, obesity, lipid disorder, previous myocardial infarction, supraventricular tachycardia, ventricular tachycardia, 2nd degree AV block and complete AV block were similar for both male and female CS patients. Following ICD implantation, the mean length of stay and mean hospital charges were comparable between the two groups. Incidence of acute kidney injury (AKI) post-ICD was more common in males (23.8% vs 15.7%, p=0.01) (Table 1).

Conclusion: AF, SSS and VF are more prevalent in female CS patients with ICD. However, ICD use in CS patients is generally more common in males who also have a greater prevalence of diabetes, CKD and post-ICD AKI.

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