DOI: 10.1161/circ.148.suppl_1.13802 ISSN: 0009-7322

Abstract 13802: Differences in the Incidences and Predictors of Major Adverse Cardiovascular Events Between in Patients With Acute and Chronic Coronary Syndromes

Shinnosuke Kikuchi, Kozo Okada, Katsuhiko Tsutsumi, Jin Kirigaya, Hidefumi Nakahashi, Yugo Minamimoto, Masaomi Gohbara, Yuichiro Kimura, Kensuke Matsushita, Masami Kosuge, Toshiaki Ebina, Teruyasu Sugano, Kiyoshi Hibi
  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Backgrounds: Patients with acute coronary syndrome (ACS) have a higher risk of the recurrence of major adverse cardiovascular events (MACE) than those with chronic coronary syndrome (CCS). However, it remains undefined whether contributing factors to recurrent MACE are different between ACS and CCS, which information may be important for the individual patient’s management.

Aims: This retrospective, single-center analysis aimed to examine and compare incidences and predictors of MACE after PCI in patients with ACS and CCS.

Methods and Results: A total of 3115 patients (2201 ACS and 914 CCS) who received PCI were enrolled and followed for a median of 2.9 years for MACE, defined as a composite of cardiovascular death, myocardial infarction (MI), revascularization, ischemic stroke, and hospitalization for heart failure (HF). Incidences of MACE, especially cardiovascular death, myocardial infarction, and stroke were significantly higher in ACS than in CCS, whereas the rates of revascularization and HF hospitalization were comparable between the groups (Table 1A). Multivariable regression analyses identified different determinants for MACE between ACS and CCS, except for previous MI (Table 1B). Similarly, risk factors were different between ACS and CCS with respect to each MACE component (data not shown).

Conclusions: Not only incidences of MACE but also their components and predictors were different between ACS and CCS. Further studies are warranted to investigate whether machine learning of electronic medical records may help enhance further risk stratification of MACE and could lead to improved clinical decision-making after PCI.

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