Abstract 13508: Baseline Lipid Profile and Risk of Atrial Fibrillation Recurrence After Atrial Fibrillation Ablation
Jack Tiahnybik, Hisaki Makimoto, Masashi Kamioka, Tanyanan Tanawuttiwat, Tomonori Watanabe, Mithilesh Das, Yasushi Imai, John Miller, Masashi Kamioka, Kazuomi Kario, Takeki Suzuki- Physiology (medical)
- Cardiology and Cardiovascular Medicine
Introduction: Dyslipidemia is a modifiable cardiovascular risk factor. However, it is unclear if baseline lipid levels prior to atrial fibrillation (AF) ablation are associated with AF recurrence.
Hypothesis: This study aimed to examine if there was an association between baseline lipid profiles and AF recurrence after AF ablation.
Methods: We retrospectively studied patients who underwent AF ablation from January 2016 to September 2021 at two high-volume international centers. Patients with a lipid profile in the previous 24 months prior to AF ablation and a one-year post-ablation follow-up with electrocardiogram were included. AF recurrence was defined as having a 12-lead electrocardiographic evidence of AF or atrial tachycardia within one year after a 3-month blanking period. Logistic regression analysis was performed to examine association of lipid profiles (low-density lipoprotein (LDL), high-density lipoprotein (HDL), total cholesterol (TC), and triglycerides) with AF recurrence. Lipid profiles were evaluated both as continuous and categorical variables. Well-established cut-points were used for LDL, and tertiles were used for HDL, TC, and triglycerides.
Results: A total of 287 patients were included in the study (mean age (SD), 63.6 (10.5), 36% female). Patients with LDL<70 mg/dL or TC < 141 mg/dL had a decreased risk of AF recurrence in unadjusted analysis. These associations remained significant after adjustment by traditional AF risk factors and statin use (odds ratios (ORs) (95% confidence interval): 0.27 (0.09 - 0.79) and 0.28 (0.09 - 0.84), respectively. TC analyzed as a continuous variable was associated with increased risk of AF recurrence (1.012 (1.002 - 1.022) per 1 mg/dL increase). (Table).
Conclusions: In our international registry, patients with LDL <70 mg/dL or TC <141 mg/dL were associated with a reduced risk of AF recurrence, suggesting a beneficial effect of low LDL and TC in patients with AF undergoing catheter ablation.