Abstract 130: Sex Differences in Survival Outcomes of OHCA Patients With Adjustment of In-Hospital Managements With Sex Disparities

Introduction: Recently, our group reported that sex differences in in-hospital management such as coronary angiography, and percutaneous coronary intervention exist. Therefore, this study aimed to determine sex differences in survival outcomes of out-of-hospital cardiac arrest (OHCA) after adjusting prehospital and in-hospital variables.

Methods: This is a retrospective observational study using prospective multicenter registry, Korean Cardiac Arrest Research Consortium. Adult OHCA patients between October 2015 and December 2021 were included. Primary outcome was survival to discharge. Multivariable logistic regression analyses were performed after adjusting prehospital and in-hospital variables.

Results: Total 10879 adult OHCA patients were analyzed. Survival to discharge and good neurologic outcomes at discharge were lower in women than men (9.4% vs. 16.6%, p<0.001 and 5.6% vs. 11.8%, p<0.001, respectively). After adjustment of prehospital and in-hospital variables (coronary angiography, percutaneous coronary intervention, targeted temperature management and extracorporeal membrane oxygenation), women were more likely to survive to discharge and have good neurologic outcome than men (adjusted odds ratio [aOR] 1.20, 95% confidence interval [CI] 1.02-1.43, p=0.033 and aOR 1.48, 95% CI 1.18-1.85, p<0.001, respectively). The sex difference in survival to discharge pronounced in age from 45 to 74, and the sex difference in good neurologic outcome pronounced in age from 45 to 84.

Conclusion: After adjusting prehospital and in-hospital variables, women with OHCA were more likely to survive to discharge and have good neurologic outcome than men.